The discovery of leucine rich repeat containing g protein coupled receptor 5 lgr5 as both a marker of adult stem cells and a critical modulator of their activity via its role as an effector of wnt r spondin rspo signaling has driven major advances in our understanding of stem cell biology during homeostasis regeneration and disease. What is an extracellular matrix ecm the ecm is the structural and functional substance that surrounds cells in nearly all tissues in the body. Myoepithelial cell myoepithelial cells are true epithelial cells that form desmosomes and hemidesmosomes with cadherin mediated cell junctions
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